Biofilm Eradication With Biodegradable Modified-Release Antibiotic Pellets
نویسندگان
چکیده
منابع مشابه
Biofilm eradication with biodegradable modified-release antibiotic pellets: a potential treatment for glue ear.
OBJECTIVE To develop a biodegradable, modified-release antibiotic pellet capable of eradicating biofilms as a potential novel treatment for biofilm infections. DESIGN Pellets containing poly(DL-lactic-co-glycolic acid) microparticles, rifampin and clindamycin hydrochloride (3.5%, 7%, or 28% antibiotic by weight), and carrier gel (carboxymethylcellulose or poloxamer 407) were tested in vitro. ...
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Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment of infections. Nanomedicines such as chitosan can carry multiple drugs and improve the therapeutic effects of antibiotics. Objectives: The study aimed to synthesis and characterization of ciprofloxacin loaded chitosan nanoparticle for eradication biofilm of P. aeroginosa. Methods: Cipro-CS microparticles...
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Bacterial infection in orthopaedic surgery can be devastating, and is associated with significant morbidity and poor functional outcomes, which may be improved if high concentrations of antibiotics can be delivered locally over a prolonged period of time. The two most widely used methods of doing this involve antibiotic-loaded polymethylmethacrylate or collagen fleece. The former is not biodegr...
متن کاملDevelopment of a modified-release pellets formulation--with metoprolol tartrat and kinetic aspects of in vitro release.
AIM The development of a new pellets formulation which is able to modulate the release of metoprolol tartrate, an active pharmaceutical ingredient very soluble in water and therefore very difficult to process. MATERIALS AND METHODS Two types of different viscosity grade hydroxypropyl methylcellulose (Methocel K100; HPMC 15.000) and Eudragit NE30D are used as prolonged drug release agents, thu...
متن کاملNew Perspectives in Biofilm Eradication.
Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to public health. Immunocompromised patients, individuals who require implanted devices, artificial limbs, organ transplants, or external life support and those with major injuries or burns, are particularly prone...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2012
ISSN: 0886-4470
DOI: 10.1001/archotol.2013.238